KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
37.27
Human Site:
S619
Identified Species:
68.33
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
S619
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S661
H
P
R
R
I
N
V
S
P
T
T
Y
Q
L
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
S673
H
P
R
R
I
N
V
S
P
T
T
Y
Q
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
S619
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
Rat
Rattus norvegicus
P19686
690
77548
S618
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
S619
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
Chicken
Gallus gallus
XP_420375
688
77848
S617
V
P
R
K
I
N
V
S
P
T
T
Y
R
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
C562
Y
T
R
F
D
Y
Q
C
G
I
L
D
V
Y
K
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
N611
G
N
N
V
T
L
A
N
K
F
E
S
C
S
Q
Fruit Fly
Dros. melanogaster
Q07093
676
75644
S604
E
A
L
K
I
N
V
S
P
T
T
K
D
W
L
Honey Bee
Apis mellifera
NP_001011650
699
78655
S629
E
P
L
R
I
H
V
S
P
T
T
Y
I
L
L
Nematode Worm
Caenorhab. elegans
O02298
688
78384
T595
R
G
K
G
M
M
Y
T
Y
F
L
E
R
N
D
Sea Urchin
Strong. purpuratus
P16065
1125
126238
S1055
L
A
L
R
I
H
V
S
P
W
C
K
Q
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
80
N.A.
80
N.A.
100
100
N.A.
100
100
N.A.
6.6
0
60
66.6
6.6
33.3
P-Site Similarity:
100
93.3
N.A.
93.3
N.A.
100
100
N.A.
100
100
N.A.
6.6
6.6
60
80
26.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
8
0
8
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
8
8
0
8
% D
% Glu:
16
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
16
0
0
0
0
0
% F
% Gly:
8
8
0
8
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
16
0
0
0
0
16
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
77
0
0
0
0
8
0
0
8
0
0
% I
% Lys:
0
0
8
47
0
0
0
0
8
0
0
16
0
0
8
% K
% Leu:
8
0
24
0
0
8
0
0
0
0
16
0
0
62
77
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
62
0
8
0
0
0
0
0
8
0
% N
% Pro:
0
62
0
0
0
0
0
0
77
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
24
0
8
% Q
% Arg:
8
0
62
31
0
0
0
0
0
0
0
0
47
0
0
% R
% Ser:
0
0
0
0
0
0
0
77
0
0
0
8
0
8
0
% S
% Thr:
0
8
0
0
8
0
0
8
0
70
70
0
0
0
0
% T
% Val:
39
0
0
8
0
0
77
0
0
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% W
% Tyr:
8
0
0
0
0
8
8
0
8
0
0
62
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _